Excitotoxicity, a pathologic process caused by excessive stimulation by neurotransmitters, is commonly associated with acute nerve cell damage, such as stroke, traumatic brain injury (TBI) and stroke, as well as neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), Parkinson's disease, Huntington's disease, and others
In the USA alone, every year about 800 thousand people have a stroke, with this medical condition being a leading cause of disability in the United States. It is estimated that 3.2 million–5.3 million persons in the United States are living with a TBI-related disability.
5.8 million patients with Alzheimer's disease, and 1 million patients with Parkinson's disease seeking for life-saving medications. In most of such cases, the therapeutic options are minimal. An effective neuroprotective agent could bring new hope to millions of patients